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Local and Systemic Management of Primary Breast Cancers Masakazu Toi and Eric P. Winer (eds)

Making a consensus on “local and systemic management” – Based on Kyoto Breast Cancer Consensus Conference 2009 (April), Local and Systemic Management of Primary Breast Cancers, edited as an academic handbook, covers cutting-edge treatments on breast cancer with the best expertise from the world. Local and systemic management approach to breast cancer enables concerning clinical physicians to provide patients with the optimal treatment. The volume wraps up well-balanced correspondence of detailed follow-ups to clinical data in 9 chapters with its deliberative process (from questionnaires, voting results to succeeding discussion) appended to each session.


"With over 10 years experience in preoperative therapy, the KBCCC editors of Local and Systemic Management of Primary Breast Cancers provide a comprehensive viewpoint on preoperative therapy and offer guidance to clinicians for patient management as well as outline important areas of controversy that require further research."
----Dr. V. Suzanne Klimberg, University of Arkansas for Medical Sciences, USA

"The two editors of this comprehensively peer-reviewed material have succeeded in integrating local management to the framework of systemic management. Local and Systemic Management of Primary Breast Cancers is highly recommended not only for physicians who major in the study of breast cancer, but also oncologists, radiologists, pathologists and interns who seek to major in the study of breast cancer."
----Dr. Tadashi Ikeda, Teikyo University, Japan

"A book that breast cancer clinicians should have on their book shelves.
This book covers a range of interesting topics including systemic treatment, novel therapies against HER-2 and other biomarkers, discussion on optimal local therapy after neoadjuvant therapy and post-neoadjuvant treatment options for those with residual disease. It is the conjoint efforts from a group of world experts sharing also the valuable Asian perspectives and experiences on breast cancer."
----Dr. Louis W.C. Chow, OOTR, Hong Kong


Prefaratory Note:
Hiroshi Sonoo (Chairman of the Board of Directors, Japanese Society of Breast Cancer, Professor of Kawasaki Medical University, Japan)

Chapter 1: Overview and Future Perspectives of Primary Breast Cancer
John Forbes (The University of Newcastle, Australia)

Chapter 2: Axillary Diagnosis and Treatment
- Section A. Ultrasound for Axillary Staging
Chiun-Sheng Huang (National Taiwan University, Taiwan)
- Section B. Bio-optical Aspects in Indocyanine Green Fluorescence for Sentinel Node Biopsy in Breast Cancer
Toshiyuki Kitai (Nara Social Insurance Hospital, Japan)
- Section C. Axillary Node Assessment and Treatment after Neo-adjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer
Eun Sook Lee (Korea University, Korea)
- Section D. Current Status of Sentinel Node Biopsy for Breast Cancer in Japan
Seigo Nakamura (St. Luke's International Hospital, Japan)
- Section E. Controversy of Axillary Diagnosis and Treatment
Tomoharu Sugie (Kyoto University, Japan)

Chapter 3: Optimal Breast Surgery
- Section A. Optimum Breast Surgery
John Benson (Addenbrooke's Hospital and the University of Cambridge, UK)
- Section B. Local Management of Primary Breast Cancer Optimal Breast Surgery
Nasim Ahmadiyeh and Mehra Golshan (Brigham and Woman's Hospital and Dana Farber Cancer Institute, USA)
- Section C. Optimal Surgery for Breast Cancer
Michail Shafir (The Mount Sinai Hospital, USA)
- Section D. Optimal Breast Surgery: Questionnaire about Optimal Surgery for Breast Cancer at Kyoto Breast Cancer Consensus Conference (KBCCC) in 2009
Takashi Inamoto (Kitano Hospital, Japan)

Chapter 4: Pathology
Histopathologic Prognostic Factors of Early Breast Cancer
Yoshiki Mikami (Kyoto University, Japan) and Hironobu Sasano (Tohoku University, Japan)

Chapter 5: Genetics-personal Genomics Data
Dimitrios Roukos and Dimosthenis Ziogas(Ioannina University, Greece)

Chapter 6: Radiation therapy
- Section A. New Strategies of Radiotherapy in Patients with Early Breast Cancer
Rodrigo Arrigada (Institute Gustave Roussy, France / Karolinska Institutet, Sweden)
- Section B. Postmastectomy Radiotherapy in 'Intermediate-risk' Breast Cancer
Ian Kunkler (The University of Edinburgh, UK)
- Section C. Current Pattern of Care in Radiation Therapy in Korea, China and Japan
Sung Whan Ha (Seoul National University, Korea) , Jiayi Chen (Fudan University, China) and Michihide Mitsumori (Kyoto University, Japan)
- Section D. The Role of Radiation Therapy after Initial Chemotherapy
Eric A. Strom (The University of Texas M.D. Anderson Cancer Center, USA)

Chapter 7: Preoperative Therapy
- Section A. How to Optimize Neoadjuvant Chemotherapy in Breast Cancer Patients? - Experience of the German Breast Group (GBG)
Gunter von Minckwitz (University of Frankfurt, Germany)
- Section B. Local Management after Preoperative Chemotherapy
Raimund Jakesz (University of Vienna, Austria) and Karl Thomanek (University of Vienna, Austria)
- Section C. Local Management after Pre-operative Chemotherapy
Hiroyasu Yamashiro, Masahiro Takada and Masakazu Toi (Kyoto University, Japan)
Section D. Local Management after Pre-operative Anti-HER2 Therapy Nobuko Sakita, Takayuki Ueno and Masakazu Toi (Kyoto University, Japan)
- Section E. Local Management after Pre-operative Hormone Therapy
Hironobu Sasano (Tohoku University, Japan)

Editor's PROFILE

Masakazu Toi (Kyoto University, Japan)
Graduated from Faculty of Medicine, Hiroshima University in 1982, Dr. Toi studied abroad to Oxford University, UK in 1990 and Center of Oncology Dana Farber Cancer Institute, Harvard University in 2000. Since he came back to Japan, he taught as a professor of DDS center, Tokyo University of Science in 2003. He currently serves as a professor of Department of Breast Surgery Graduate School of Medicine Kyoto University (from 2007), a chairperson of Kyoto Breast Cancer Consensus Conference (KBCCC) and a board member of Japanese Cancer Association, Japan Society of Clinical Oncology, Japan Surgical Society and The Japanese Breast Cancer Society.

Eric P. Winer (Harvard University, USA)
Dr. Winer received his MD from Yale University in 1983, and later completed training in internal medicine and served as chief resident at Yale-New Haven Hospital. He subsequently was a fellow in hematology-oncology at Duke University Medical Center, and from 1989 to 1997 served on the Duke faculty, where he became co-director of the multidisciplinary breast program. In 1997, he joined Brigham and Women's Hospital and DFCI, where he is director of the Breast Oncology Center. He is Professor of Medicine at Harvard Medical School and the Thompson Investigator in Breast Cancer Research at Dana-Farber. He currently serves as co-chair of the CALGB breast committee, the chief scientific advisor / advisory committee chairperson of the Susan G. Komen Breast Cancer Foundation.

Ordering Information

International , except for those below
  The ISBN of International version is 978-4-87698-923-2
International Orders
Kyoto University Press
Yoshida-South Campus, Kyoto University
69 Konoe-cho Yoshida, Sakyo, Kyoto 606-8315, Japan

North America, Australasia, Southeast Asia and Taiwan
  The ISBN of Trans Pacific Press version is 978-1-92090-122-6
Orders in the United States and Canada
International Specialized Book Services
920 NE 58th Avenue, Suite 300
Portland, Oregon 97213-3786, USA
Orders in Australasia, Southeast Asia and Taiwan
Trans Pacific Press
PO Box 164, Balwyn North,
Victoria 3104, Australia


  Kyoto University Press
Yoshida South Campus,
Kyoto University
69 Konoe-cho Yoshida, Sakyo,
Kyoto 606-8315, Japan
    Trans Pacific Press
PO Box 164, Balwyn North,
Victoria 3104, Australia